释义 |
lesch-ny·han syndrome \¦leshˈnīən-\ noun also lesch-nyhan disease Usage: usually capitalized L&N Etymology: after Michael Lesch b1939 American cardiologist and William L. Nyhan b1926 American pediatrician : a rare and usually fatal genetic disorder of male children that is inherited as an X-linked recessive trait and that is characterized by hyperuricemia, mental retardation, spasticity, compulsive biting of the lips and fingers, and a deficiency of an enzyme that conserves hypoxanthine in the body by limiting its conversion to uric acid |