beef·alo \ˈbēfəˌlō\noun Etymology: blend of beef (I) and buffalo 1.usually capitalized: a breed of beef cattle developed in the United States that is genetically 5/8 domestic bovine and 3/8 North American buffalo (Bison bison) 2.pluralbeefalosorbeefaloesoften capitalized: an animal of the Beefalo breed