dis·affect I. \|dis+\transitive verb Etymology:dis- (I) + affect (have affection for) 1.archaic: to lack affection for : be alienated from : dislike 2.: to alienate or diminish the affection or loyalty of : fill with discontent and unrest < all hands were disaffected by the example of the ringleaders — R.L.Stevenson > Synonyms:see estrange II. transitive verb Etymology:dis- (I) + affect (act upon) obsolete: derange, disorder