nodular worm noun alsonodule worm 1.: any of several nematode worms (genus Oesophagostomum) that are parasitic in the large intestine of ruminants and swine where they cause swellings of the intestinal wall resembling abscesses 2.: a filarial worm (Onchocerca gibsoni) causing nodular swellings in the skin and subcutaneous tissues of Australian cattle