pas·ti·tsio \päˈstētsē(ˌ)ō, -ˈstē(ˌ)chō\noun alsopas·ti·tso\-ˈstēt(ˌ)sō\ (-s) Etymology: New Greek pastitsio, pastitso, from Italian pasticcio pie, baked pasta dish — more at pasticcio : a Greek baked dish made of ground meat layered with pasta and usually topped with white sauce and cheese