san·ta fe \|santə|fā, in sense 2 |sän-\adjective Usage: usually capitalized S&F 1.[from Santa Fe, city in north central New Mexico]: of or from Santa Fe, the capital of New Mexico < Santa Fe stores > : of the kind or style prevalent in Santa Fe 2.[from Santa Fe, city in east central Argentina]: of or from the city of Santa Fe, Argentina : of the kind or style prevalent in Santa Fe