| 释义 |
thalidomide|θəˈlɪdəmaɪd|
Also Thalidomide.
[f. phthalimidoglutarimide, f. phthalimide + -o + glutaric adj. s.v. glut- + imide.]
a. A non-barbiturate sedative and hypnotic, C13H10N2O4, which was found to be teratogenic when taken early in pregnancy, sometimes causing malformation or absence of limbs in the fœtus.
1958Lancet 1 Feb. 271 The British Pharmacopœia Commission has issued the following new supplementary list of approved names:..Thalidomide..α-Phthalimido⁓glutarimide. 1961Ibid. 2 Dec. 1262/1 We have just received reports from two overseas sources possibly associating thalidomide (‘Distaval’) with harmful effects on the fœtus in early pregnancy. 1962New Scientist 28 June 717/1 The tragic cost of the use of thalidomide. 1969N. W. Pirie Food Resources vii. 167 Thalidomide is the classic example of a substance that passed orthodox tests that were, as it turned out, not relevant. 1978Dædalus Spring 136 Passage of the 1962 drug law might not have occurred without the public demand for stricter controls over the testing of new drugs following disclosure of deformities caused by Thalidomide. 1979Nature 29 Nov. 509/1 Other agents, notably Thalidomide, are believed to be teratogenic by virtue of metabolic products rather than the parent compound.
b. attrib. and Comb.: thalidomide baby, child, etc., one born deformed through the effects of thalidomide.
1962Guardian 31 July 14/2 There is still no information about the number of ‘thalidomide babies’ in the country. 1962Lancet 1 Dec. 1155/2 Attempts have been made to lengthen stunted thalidomide arms by grafts from fibula and scapula. 1971New Scientist 18 Mar. 613/1 The construction of a body harness for armless thalidomide children. 1973Daily Tel. 9 Jan. 2/2 A Pharmaceutical Society spokesman said..that the scale of the thalidomide compensation would undoubtedly have a ‘profound effect’ on the manufacture of new drugs in Britain. 1977J. D. Douglas in Douglas & Johnson Existential Sociol. i. 26 Her highly publicized abortion in Sweden for a thalidomide-damaged fetus. 1979T. Benn Arguments for Socialism ii. 49 There was also the initial refusal by Distillers to compensate the thalidomide children properly. 1980Nature 1 May 54/1 The thalidomide tragedy, for example, could have been averted if this synthetic racemate had been separated into its optical isomers, for only the left-handed (s)-(-)-isomer has teratogenic properties. 1981Daily Tel. 3 Feb. 2/2 This is the first known case of a thalidomide victim becoming a father, although a couple of incidences of thalidomide mothers are known. |