| 释义 |
immunoglobulin Biochem. and Med.|ɪˌmjuːnəʊ-, ˌɪmjuːnəʊˈglɒbjʊlɪn|
[f. immuno- + globulin.]
Any of the group of proteins present in the serum of vertebrates which are characterized by their structure, in being a mixture of larger (‘heavy’) and smaller (‘light’) polypeptide chains, linked usu. by disulphide bonds, and by their function in that all known antibodies are immunoglobulins.
1959J. F. Heremans in Clin. Chim. Acta IV. 643 The data..seem to point to the existence of a system of closely related, though not identical, proteins which are capable of acting as antibodies. These are: (a) γ-globulin (7S, low carbohydrate content, heterogeneous mobility)..; (b) β2A-globulin (also 7S, high carbohydrate content, high mobility)..; and (c) β2M-globulin (19S, high carbohydrate content, high mobility). The outlined similarities in nature and function clearly call for the adoption of a common name for all these substances. A word such as ‘immunoglobulins’ would seem to be suitable. 1965New Scientist 11 Mar. 626/1 The body's ‘immune’ defence mechanism against bacteria, viruses and other foreign materials depends largely on the presence in the blood serum of a family of proteins known as immunoglobulins. 1970Gold & Peacock Basic Immunol. iii. 93 A new nomenclature was proposed in which the prefix γ or Ig stood for immunoglobulin and a suffix denoted the particular class of immunoglobulin. Thus the 7S, 160,000 M.W., gamma-globulins became IgG or γG, the macroglobulins became IgM or γM, and the third class of immunoglobulins, IgA or γA... Two other classes of human immunoglobulin, IgD..and IgE.., are now known. 1970Rothschild & Waldmann Plasma Protein Metabolism xvi. 259 The immunoglobulins are a group of structurally related proteins produced by plasma cells and lymphocytes. 1970Nature 12 Dec. 1040/1 These studies have shown that immunoglobulins are composed of light chains (molecular weight 23,000) and heavy chains (55,000) which are linked through disulphide bonds. 1971Ann. N.Y. Acad. Sci. CXC. 8 The lamprey has 6·6S and 14S immunoglobulins which have similar light and heavy chains. |