† insaˈnationObs.rare—1. [f. L. insānus insane, after L. sānātio, f.sānāre to heal.] A making or becoming insane; insane condition. 1599A. M. tr.Gabelhouer's Bk. Physicke 347/2 Administre therof to them..and then they shalbe protected agaynste insanation, or maddenes.