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单词 von Hippel–Lindau
释义 von Hippel–Lindau, n. phr. Path.|fɒn ˈhɪpəl ˈlɪndaʊ|
The names of Eugen von Hippel (1867–1939), German ophthalmologist, and Arvid Lindau (see *Lindau n.), used attrib. and in the possessive in von Hippel–Lindau('s) disease, syndrome, an inherited disorder characterized by the presence of haemangioblastomas in the cerebellum, in association with retinal angiomas and often with growths or cysts in the kidneys or pancreas.
1932Trans. Opthalm. Soc. LII. 395 As to the familial and hereditary origin, this is of the utmost importance. So was published by Hartmann and Sourdille a case of von Hippel–Lindau's disease in which a young man showed angiomatosis of the retina.1936Bull. Neurol. Inst. N.Y. V. 72 The Von Hippel–Lindau disease may be familial and start early in life.1961Jrnl. Amer. Med. Assoc. 21 Oct. 282/1 The great variety of lesions seen in von Hippel–Lindau's disease suggests that the lesions arise from maldevelopment or malformation in fetal life in which some aberration occurs resulting in a potentiality for neoplastic growth in later life.1970Jrnl. Med. Genetics VII. 156/2 This pedigree shows convincingly that autosomal recessive inheritance can operate as an alternative mode of transmission of Von Hippel–Lindau syndrome.1987Oxf. Textbk. Med. (ed. 2) II. xxi. 171/1 Tuberose sclerosis is associated with periventricular glioma, and von Hippel–Lindau disease with cerebellar haemangioblastoma.
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