| 释义 |
propantheline Pharm.|prəʊˈpænθəliːn|
[f. propyl + xanthene + -el (f. ethyl) + -ine5.]
A white, bitter-tasting powder, C23H30NO3Br, which is a quaternary ammonium bromide derived from xanthene, and is a parasympatholytic agent used esp. for treating the symptoms of peptic ulceration. Also propantheline bromide. Cf. Pro-Banthine.
1954Brit. Jrnl. Pharmacol. IX. 218 (heading) A comparison of the peripheral parasympatholytic and autonomic ganglion blocking activities of methantheline (‘Banthine’) and propantheline (‘Pro-Banthine’) with atropine and hexamethonium. Ibid. Propantheline (2′-diisopropylaminoethyl xanthene-9-carboxylate methobromide) is the isopropyl analogue of methantheline and differs from it only in degree of activity.., its actions being qualitatively similar. 1955Lancet 10 Sept. 526/2 Propantheline bromide can be used to relieve colic, whether due to spasm of the sphincter or associated with biliary reflux and pancreatitis. 1958[see Pro-Banthine]. 1970O. L. Wade Adverse Reaction to Drugs ii. 13 Atropine or propantheline in the doses required to reduce gastric motility and gastric secretion in the treatment of peptic ulcer may cause unpleasant dryness of the mouth or blurring of vision. 1977Lancet 26 Nov. 1134/1 The effects of propantheline bromide on the eyes should be considered when the drug is used in the treatment of hyperhidrosis. |