| 释义 |
myeloblast Anat.|ˈmaɪələʊblɑːst, -æ-|
[a. G. myeloblast (O. Naegeli 1900, in Deutsche med. Wochenschr. 3 May 289/1): see myelo- and -blast.]
Any of the immature cells (approximately 15 microns in diameter, with large nuclei and a small amount of densely staining cytoplasm) which are confined to the bone marrow, appearing in the circulating blood only in pathological states, and which, according to the so-called monophyletic (unitary) theory of hæmopoiesis, are the precursors of all other myeloid cells of the blood and bone marrow, or, according to the diphyletic (dualistic) or polyphyletic theories, are the precursors only of the myelocytes and of cells derived from them.
1904F. P. Foster Appleton's Med. Dict. 1395/1 Myeloblast. 1909R. J. M. Buchanan Blood in Health & Dis. viii. 143 Nägeli termed them ‘myeloblasts’. 1911W. K. Hunter Rec. Adv. Hæmatol. 30 Both the neutrophile and the eosinophile myelocyte are, according to Ehrlich, originally derived from a cell to which the name myeloblast has been given. 1961Lancet 19 Aug. 434/2 The leucoerythroblastosis persisted, although granulocyte precursors, occasionally including myeloblasts, became more numerous than the nucleated red cells in the peripheral blood. 1968Passmore & Robson Compan. Med. Studies I. xxvi. 11/2 After birth, the production of the granulocytic white cells takes place only in the red marrow... The first stage of development is the myeloblast.
So myeloˈblastic a., of, pertaining to, or involving myeloblasts; ˌmyeloblaˈstosis [-osis], the condition of having large numbers of myeloblasts in the bone marrow and circulating blood.
1916L. F. Barker Monographic Med. III. 214 The cells of these myeloblastic proliferations. 1924Jrnl. Exper. Med. XL. 845 (heading) Studies on the maturation of myeloblasts into myelocytes and on amitotic cell division in the peripheral blood in subacute myeloblastic leucemia. 1937Kracke & Garver Dis. Blood v. 65 A true myeloblastosis, in which the myeloblast is the predominant cell type in both the bone marrow and peripheral blood, occurs only in the terminal, exacerbation stage of chronic myelosis and in acute myeloblastic leukemia. 1938H. Downey Handbk. Hematol. III. xxv. 2014 They [sc. the cells] are clearly of the myeloblastic type. 1965New Scientist 17 June 800/2 The three main leukaemias of poultry—lymphomatosis, erythroblastosis and myeloblastosis—are caused by filterable transmissible agents. 1974Passmore & Robson Compan. Med. Studies III. xxi. 62/1 (table) Acute myeloblastic leukaemia. |