| 释义 |
myelomatosis Path.|ˌmaɪələʊməˈtəʊsɪs|
[f. myelomat- (taken as stem of myeloma) + -osis.]
A malignant proliferation of plasma cells causing numerous accumulations of them to form in the bone marrow and abnormal proteins to be present in the blood and urine.
1904Jrnl. Path. & Bacteriol. IX. 173 At the necropsy the bone marrow of all the bones examined was found to be more or less affected by a diffuse sarcoma-like growth of rounded or polyhedral mononuclear cells—a form of ‘multiple myeloma’ or ‘myelomatosis’. 1906Jrnl. Amer. Med. Assoc. 16 June 1893/2 Hoffmann defines myelomatosis as the multiple development of malignant tumors in the bone marrow, originating in hyperplasia of one of the cellular elements of the mother soil [sic: ? read cell] (lymphocyte, myelocyte, plasma cell). 1961Lancet 16 Sept. 639/2 Neither in myelomatosis in man nor in any of the plasmacytomas of mice..do we ever regularly observe a direct Coombs test or signs of hæmolytic anæmia. 1966Wright & Symmers Systemic Path. II. xxxix. 1419/2 Myelomatosis or multiple myeloma is a neoplastic condition originating from the bone marrow. |