释义 |
nalidixic, a. Pharm.|nælɪˈdɪksɪk| [f. parts of the systematic name of the acid rearranged.] nalidixic acid, an antiseptic, C12H12N2O3 , which inhibits bacterial reproduction, and is given orally in the treatment of infections of the urinary tract; 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid.
1962Jrnl. Med. & Pharmaceutical Chem. V. 1064 The antibacterial activity of nalidixic acid has been demonstrated against a variety of microorganisms causing disease in man and animals. 1976Nature 15 Apr. 643/1 Nalidixic acid (NAL) has been described as a specific inhibitor of bacterial DNA synthesis in vivo and in vitro, but its mechanism of action on susceptible bacteria remains obscure. 1977Lancet 13 Aug. 343/1 Since the age of 3 she had been on continuous antibiotics which included co-trimoxazole, amoxycillin, nalidixic acid, [etc.]. 1988Med. Clin. N. Amer. LXXII. 624 High level resistance of bacteria to nalidixic acid developed rapidly after the introduction of the drug in the early 1960s. |