| 释义 |
nicotinamide Biochem.|nɪkəʊˈtɪnəmaɪd|
[f. nicotinic a. + amide.]
a. The amide, (C5H4N)CONH2, of nicotinic acid, which can be converted into the acid in vivo and so can replace it in the diet.
1895Jrnl. Chem. Soc. LXVIII. i. 391 On heating ethylic nicotinate with alcoholic ammonia..it is converted into nicotinamide, which melts at 121°. 1951in M. McLuhan Mech. Bride (1967) 91/1 (Advt.), It is nicotinamide, an important component in the familiar Vitamin B Complex pill. 1957A. Huxley Let. 12 Dec. (1969) 837 The Italians have been using massive doses of Nicotinamide (a variant on nicotinic acid) in psychological cases for some time. 1968Passmore & Robson Compan. Med. Stud. I. v. 14/2 In Great Britain, the U.S.A. and many other countries, nicotinamide must by law be added to white flour used for bread making.
b. Comb. nicotinamide-adenine dinucleotide, a compound of adenosine monophosphate and nicotinamide mononucleotide which is a co-enzyme for the oxidation of a wide variety of substrates in vivo; NAD; co-enzyme I; diphosphopyridine nucleotide.
1961Biochem. Jrnl. LXXX. 323/1 The rate of formation of nicotinamide-adenine dinucleotide from adenosine triphosphate..and nicotinamide mononucleotide..was measured. 1969J. R. Holum Introd. Org. & Biol. Chem. xi. 381 Nicotinamide (niacinamide) is a vitamin used by the body in making the coenzyme nicotinamide adenine dinucleotide. |