| 释义 |
niridazole, n. Pharm.|ˌnaɪˈrɪdəzəʊl|
[f. nitro- + imidazole n.]
An anthelminthic drug which has been used in the treatment of schistosomiasis and is usually given orally; 1-(5-nitrothiazol-2-yl) imidazolidin-2-one, C6H6N4O3S .
1966Brit. Med. Jrnl. 19 Nov. 1261/2 A male child aged 17 months weighing 23 lb. 14 oz. (11 kg.) recently died in the Mwanza General Hospital following Ambilhar (niridazole) therapy. 1968Sci. Jrnl. Oct. 7/1 It is only some two years ago that CIBA scientists achieved the breakthrough that made niridazole, better known as Ambilhar, available as an alternative to the harsh antimony drugs. 1978Nature 22 June 628/1 The development of niridazole has provided an important new therapy for schistosomiasis due to Schistosoma haematobium. 1985Ann. Rev. Pharmacol. & Toxicol. XXV. 499 Factors other than the need for multiple dosing and the occurrence of occasional severe CNS side effects, which militate against the clinical acceptability of niridazole, are immunosuppression.., mutagenicity, and carcinogenicity. |