| 释义 |
Paget Path.|ˈpædʒɪt|
The name of Sir James Paget (1814–99), English surgeon, used in the possessive to designate: a. A disease (also called osteitis deformans) that affects chiefly the elderly and is often symptomless, being characterized by the localized alteration of tissue in one or more bones (most often in the spine, skull, or pelvis), which become thickened and may undergo fracture or bending.
1877Guy's Hosp. Rep. XXII. 337 (heading) Osteoporosis or Paget's osteitis deformans. 1889Index-Catal. Library Surg.-General's Office, U.S. Army X. 353/2 (heading) Paget's disease of the bones. See osteitis deformans. 1939Times 18 May 4/6 Dr. Alexander Wilson said that Mr. Desnos had Paget's disease—the bones of his skull were brittle and at least 50 per cent. softer than a normal skull. 1963Lancet 5 Jan. 34/2 In Paget's disease stones are formed as a result of increased excretion of calcium due to increased turnover of bone. 1966Wright & Symmers Systemic Path. II. 1390/2 Paget's disease is a precancerous condition. 1974Passmore & Robson Compan. Med. Stud. III. xxvi. 17/2 Paget's disease is rarely a painful disorder in the absence of complications such as fracture, tumour or arthritis.
b. A reddish eczematous condition of the skin associated with cancer of the underlying tissue and usually occurring in the female nipple; freq. called Paget's disease of the nipple; so Paget († or Paget's) cell, a large cell with clear cytoplasm and hyperchromatic nuclei found in the epidermis of the affected area.
1880Brit. Med. Jrnl. 24 Jan. 128/1 As attention was first called to it by Sir James Paget, he [sc. J. E. Erichsen] would suggest for it the name ‘Paget's disease’ of the nipple. 1910Jrnl. Cutaneous Dis. XXVIII. 383 The epidermis..contained many of the large round, so-called Paget cells. 1917Lancet 7 Apr. 519/2 The degenerate deeper layers of the epidermis..contain the large clear cells known as Paget's cells. 1923Brit. Jrnl. Surg. XI. 317 Carcinoma in the breast, with which Paget's disease of the nipple is usually associated, is a primary carcinoma of the breast epithelium. 1954Jrnl. Obstetr. & Gynæcol. LXI. 758 (heading) Histochemical characterization of the specific cells in Paget's disease of the vulva. 1966Wright & Symmers Systemic Path. I. xxviii. 995/2 Paget's disease of the breast..accounts for between 2 and 3 per cent of all mammary carcinomas. Ibid. 996/2 Patients with Paget's disease are still very likely to be treated for supposed dermatitis of the nipple. 1974Passmore & Robson Compan. Med. Stud. III. xxx. 9/2 Some believe that the Paget cells represent intra-epidermal spread of this [sc. cancer]. |