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单词 phorbol
释义 phorbol Chem.|ˈfɔːbɒl|
[a. G. phorbol (Flaschenträger & Boehm 1927, in Ber. über die ges. Physiol. und exper. Pharmakol. XLII. 585), f. Gr. ϕορβή fodder, forage (f. ϕέρβειν to feed): see -ol.]
A tetracyclic compound, C20H28O6, some of the esters of which are cocarcinogens and are present in croton oil.
1935Chem. Abstr. XXIX. 2533 Phorbol (C20H28O6 or C20H30O6) with very dilute H2SO4 in N2 gives 38% crotophorbolon.1939Thorpe's Dict. Appl. Chem. (ed. 4) III. 434/2 Phorbol and the product of its benzoylation are physiologically inactive, but the (? tetra-)acetate is highly toxic.1967Chem. & Engin. News 16 Oct. 42/1 A possible absolute configuration of phorbol, polyfunctional parent alcohol of tumor-promoting compounds in croton oil, has been determined.1978Nature 17 Aug. 640/2 The most powerful known tumour promotors are the phorbol esters, which are not carcinogenic in themselves but can induce tumour growth after a subthreshold dose of carcinogen.
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