| 释义 |
benzodiazepine Chem. and Pharm.|bɛnzəʊdaɪˈæzəpiːn|
[f. benzo- + di-2 + azo- + -epine, suffix denoting a seven-membered ring containing nitrogen, (f. hepta- + -ine5).]
Any compound whose molecule contains a benzene ring fused to a seven-membered ring containing two nitrogen atoms; spec. any of a group of such compounds used as hypnotics and anxiolytics and sometimes causing psychological dependence.
1934Chem. Abstr. XXVIII. 8031 C6-C5N2 Benzodiazepine. 1960Jrnl. Pharmacol. & Exper. Therap. CXXIX. 163/1 Methaminodiazepoxide HCl (Librium HCl) is a psychosedative drug of a new chemical type... Methaminodiazepoxide..is 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride. 1961Current Therapeutic Res. III. 424 Valium is a new psychotherapeutic agent in the 1,4-benzodiazepine class. 1968Chem. Rev. LXVIII. 748/1 The 1,4-benzodiazepines form the most extensively explored group in this series, largely owing to the discovery of their interesting biological activity, which has led to the introduction of four drugs... The 1,5-benzodiazepines have been thoroughly studied during a period of several decades, largely because of their relatively easy synthesis. 1976Lancet 30 Oct. 936/2 Barbiturates or benzodiazepines were given to ensure sleep during the preceding night. 1984A. Smith Mind iv. xiv. 265 Over sixty million prescriptions for benzodiazepines are filled in annually. |