† caˈcopathyObs.rare. [mod.ad.Gr. κακοπάθεια distress, misery, f. κακοπαθής suffering ill.] An old term for a severe affliction or malady. [1708–21Kersey, Cacopathia.]1721–90Bailey, Cacopathy, a suffering of evil, or lying under a painful disease.1860in Mayne Exp. Lex.