| 释义 |
concanavalin Biochem.|kɒnkəˈnævəlɪn|
[f. con- + canavalin (see quot. 1917), f. mod.L. Canavalia, generic name of the jack bean (f. native name in Malabar + -ia1): see -in1.]
Either of two globulins (concanavalin A, B) orig. isolated from the jack bean; spec. concanavalin A, a powerful agglutinin of blood.
1917Jones & Johns in Jrnl. Biol. Chem. XXVIII. 68 Fractional precipitation of the globulin obtained from the jack bean..enabled us to isolate two globulins... The globulin obtained in the greatest amount..we have named canavalin. Associated with canavalin was..a second globulin which was less soluble and had a much higher sulfur content. To this globulin we have given the name concanavalin. 1919J. B. Sumner in Ibid. XXXVII. 137 The minute amount of material which crystallizes as needles is slowly soluble in 10 per cent salt solution... The author has named this globulin concanavalin B. The third globulin, crystallizing in bisphenoid form, and present in moderate amount, appears to be insoluble in any but concentrated salt solutions... The author proposes to name this globulin concanavalin A. 1935Jrnl. Immunol. XXIX. 134 We made solutions of canavalin, concanavalin A, concanavalin B, jack bean proteose, and an amorphous..jack bean protein and found that although some agglutinin was present in all of these solutions the activity was slight in relation to the amount of protein in solution. 1936Jrnl. Bacteriol. XXXII. 229 Concanavalin A readily agglutinates erythrocytes from pH 5·2 to pH 7·5. 1974N. Sharon in J. B. Pridham Plant Carbohydrate Biochem. xvi. 237 Immobilized concanavalin A has been used for the isolation of immunoglobulins and of glycoprotein enzymes. 1983Oxf. Textbk. Med. I. iv. 29/2 The plant lectins concanavalin A and phytohaemagglutinin (PHA) are..activators of T cells which induce markedly polyclonal blast transformation with DNA synthesis, and this effect is used as a broad in vitro test of T cell function. |