| 释义 |
sotalol Pharm.|ˈsəʊtəlɒl|
[Etym. unkn.: see -ol.]
The compound, CH3.NH(SO2).C6H4.CH(OH).CH2.NH.CH(CH3)2, a beta-adrenergic blocking agent used (in the form of its hydrochloride) in the treatment of cardiac arrhythmias.
1968Jrnl. Pharmacol. & Exper. Therapeutics CLX. 231 The antiinflammatory action of morphine is reversed by nalorphine but not by a beta adrenergic blocking agent, sotalol (MJ 1999; 4-(2-isopropylamino-1-hydroxylethyl)-methanesulphonalinide hydrochloride). 1974R. G. Shanks et al. in A. G. Snart Adv. in Beta-Adrenergic Blocking Therapy—Sotalol I. 24 Sotalol is the only drug which blocks all adrenergic β-receptors and has no membrane stabilizing activity or intrinsic sympathomimetic activity. 1978Nature 19 Oct. 596/2 In contrast, β-adrenergic antagonists lacking the hydrophobicity of propranolol, such as atenolol, practolol and sotalol, are not able to induce meiosis. |