| 释义 |
spliceosome, n. Cytol.|ˈsplaɪsəʊˌsəʊm|
[f. splice v. + -o1 + -some4.]
A large ribonucleoprotein complex involved in splicing mrna.
1985Brody & Abelson in Science 24 May 967/2 The complex is stable enough to be only slightly modified at 400 mM KCl.., and we think that this stability reflects the importance of this structure. We propose that this particle be called a ‘spliceosome’. 1985P. J. Grabowski et al. in Cell XLII. 352/1 Since the 60S complex described here may be a cellular entity essential for splicing, we suggest the term spliceosome (splicing body). 1986Science 19 Sept. 1294/2 The structure of the spliceosome is probably the final determinant in the specificity of splicing. 1987Nature 8 Oct. 489/3 The third zone..binds rna and has some similarities to the proteins of ‘spliceosomes’. 1988Sci. Amer. June 41/1 It turns out that snRNP's [sc. small nuclear ribonucleoproteins] and their pre-mRNA substrate probably account for no more than a third to half of the mass of a spliceosome. |