It also binds to the allosteric site of the serotonin transporter, similarly, but less potently than escitalopram.

People with depression may have differences in serotonin transporter gene length.

It also has a reduced selectivity for the serotonin transporter.

Site-directed chemical labeling experiments verified the predicted topological organization of the serotonin transporter.

Such studies use a radioligand that binds -- preferably selectively -- to the serotonin transporter so an image can be formed that quantifies the distribution of the serotonin transporter in the brain.