The new discovery was that it reduced the systemic inflammation now understood to be a key factor behind ageing.

But soon it was discovered that the patients were experiencing symptoms of systemic inflammation.

The second hypothesis suggests that neutrophils accumulate and are primed in the patient's pulmonary microvasculature as a result of preexisting systemic inflammation.

These receptors also mediate severe illness, including shock and systemic inflammation as it occurs in the course of an infection.

This may result in a reduction in systemic inflammation.