(a) a book written by hand (as distinct from printed); a notebook containing, or designed for, handwritten material; (b) Music (more fully manuscript…

A book, document, etc., written by hand, esp. one written before the general adoption of printing in a country; a handwritten copy of an ancient text.

A manuscript. Frequently attributive.

A manuscript volume or book, consisting of pages bound to a spine and encased in protective covers. Frequently with reference to, or in the names…

As a count noun: a manuscript or document written on material made from the papyrus plant (see sense 3).