One who or that which tranquillizes; spec. any of a large class of drugs in widespread use since the 1950s for the reduction of tension or…

(a) (a tablet of) any of various drugs, spec. marijuana; a barbiturate tablet or drug; (b) = sense a above.

= goof ball n. (a).

A pill or tablet of a recreational or non-medicinal drug, spec. a barbiturate or amphetamine. Cf. earlier pep pill, n.

slang. A barbiturate drug. Cf. black bomber n. at black, adj. n.compounds 1e(a).

U.S. slang. A capsule containing the barbiturates quinalbarbitone and amylobarbitone (cf. Tuinal, n.). Now rare.

slang. A depressant or tranquillizing drug, especially a barbiturate. Cf. upper, n.2 1, down, n.4 1d.

A depressant or tranquillizing drug, especially a barbiturate; = downer, n. 4. Cf. uppie, n.

slang (originally U.S.). A depressant or tranquillizing drug, especially a barbiturate; = downer, n. 4. Cf. up, n. 7. Frequently in plural.

(a) U.S. a Quaalude tablet (rare); (b) originally and chiefly British a tablet of ecstasy (MDMA).