dihydropyridinen.

Brit.

/ˌdʌɪhʌɪdrə(ʊ)ˈpɪrᵻdiːn/, U.S.

/ˈˌdaɪhaɪdroʊˈpɪrəˌdin/,

/ˈˌdaɪhaɪdroʊˈpɪrədn/

Origin: Formed within English, by compounding; modelled on a German lexical item. Etymons: dihydro- comb. form, pyridine n.

Etymology: < dihydro- comb. form + pyridine n., after German Dihydropyridin (1880 or earlier).

Chemistry and Pharmacology.

Each of the five possible isomers produced by the double hydrogenation of pyridine; C₅H₇N. Also: any of various compounds derived from these; esp. any of a class of drugs derived from 1,4-dihydropyridine (in which the nitrogen and the carbon opposite to it in the pyridine ring are hydrogenated), which act as calcium channel blockers and are used chiefly for the treatment of hypertension and angina pectoris.

ΚΠ

1886 Philos. Trans. 1885 (Royal Soc.) 176 518 According to Wischnegradsky..nicotine is an alkyl derivative of a di-hydro-pyridine.

1903 Jrnl. Chem. Soc. 84 i. 651 In the present paper, evidence is adduced for the existence of open chain compounds, containing nitrogen, which..do not form dihydropyridines.

1949 Jrnl. Amer. Chem. Soc. 71 4003/1 The first products obtained were all of the normal dihydropyridine type, and manifested weak analgesic and curare-like activities.

1972 Jrnl. Pharmacy & Pharmacol. 24 917 (title) Dihydropyridines with potent hypotensive activity prepared by the Hantzsch reaction.

1989 Science 10 Feb. 809 Nimodipine is one of several dihydropyridines that block calcium channels.

2000 Saga Mag. Feb. 100/3 Dihydropyridine calcium antagonists are suitable alternatives for older patients when thiazides are ineffective or not tolerated.

This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	dihydropyridine
释义	dihydropyridinen. Brit. /ˌdʌɪhʌɪdrə(ʊ)ˈpɪrᵻdiːn/, U.S. /ˈˌdaɪhaɪdroʊˈpɪrəˌdin/, /ˈˌdaɪhaɪdroʊˈpɪrədn/ Origin: Formed within English, by compounding; modelled on a German lexical item. Etymons: dihydro- comb. form, pyridine n. Etymology: < dihydro- comb. form + pyridine n., after German Dihydropyridin (1880 or earlier). Chemistry and Pharmacology. Each of the five possible isomers produced by the double hydrogenation of pyridine; C₅H₇N. Also: any of various compounds derived from these; esp. any of a class of drugs derived from 1,4-dihydropyridine (in which the nitrogen and the carbon opposite to it in the pyridine ring are hydrogenated), which act as calcium channel blockers and are used chiefly for the treatment of hypertension and angina pectoris. ΚΠ 1886 Philos. Trans. 1885 (Royal Soc.) 176 518 According to Wischnegradsky..nicotine is an alkyl derivative of a di-hydro-pyridine. 1903 Jrnl. Chem. Soc. 84 i. 651 In the present paper, evidence is adduced for the existence of open chain compounds, containing nitrogen, which..do not form dihydropyridines. 1949 Jrnl. Amer. Chem. Soc. 71 4003/1 The first products obtained were all of the normal dihydropyridine type, and manifested weak analgesic and curare-like activities. 1972 Jrnl. Pharmacy & Pharmacol. 24 917 (title) Dihydropyridines with potent hypotensive activity prepared by the Hantzsch reaction. 1989 Science 10 Feb. 809 Nimodipine is one of several dihydropyridines that block calcium channels. 2000 Saga Mag. Feb. 100/3 Dihydropyridine calcium antagonists are suitable alternatives for older patients when thiazides are ineffective or not tolerated. This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022). < n.1886
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