fibrinoidn.
/ˈfʌɪbrᵻnɔɪd/, /ˈfɪbrᵻnɔɪd/, U.S. /ˈfaɪbrəˌnɔɪd/ Pathology.
Any of one or more poorly characterized substances staining like fibrin, found normally in the placenta as well as in various diseased tissues. Also attributive, as fibrinoid degeneration, fibrinoid necrosis.
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the world > life > the body > vascular system > blood > components of blood > [noun] > fibrin
coagulable lymph1782
fibrin1800
histin1854
fibrinoid1910
1910 Practitioner Jan. 43 The muscle so invaded stains feebly, and the presence of these cells in them has brought about a fibrinoid or necrotic change.
1958 Amer. Jrnl. Med. Sci. 236 373 Most authorities now agree that the term fibrinoid should be reserved for an intensely acidophilic (eosinophilic), homogeneous, dense and refractile substance with staining characteristics similar to those of fibrin. In the long interval since Neumann's publication much investigation..has failed to resolve the conflicting opinions regarding the origin and nature of fibrinoid.
1964 S. Duke-Elder Parsons' Dis. Eye (ed. 14) xvii. 226 A proliferative infiltration by chronic inflammatory cells surrounding a central area of fibrinoid necrosis.
1967 C. W. M. Adams Vascular Histochem. vii. 265 More severe stenosis..results in rapidly developing hypertension and ‘fibrinoid’ degeneration.
1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. xxx. 3/2 The term fibrinoid belongs to an age of pathology before the cryostat, the integrating micro~densitometer and the technique of immunofluorescence... In spite of this, the term fibrinoid will probably continue to be used to describe a characteristic appearance under light microscopy in a variety of diseases.
This entry has not yet been fully updated (first published 1933; most recently modified version published online March 2022).
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n.1910