anterogradeadj.
/ˈantərə(ʊ)ˌɡreɪd/, U.S. /ˈæntə(ˌ)roʊˌɡreɪd/ 1. Surgery and Medicine. Of an operation or procedure: performed in the direction of normal flow or movement (typically forwards, or proximal to distal). Also: utilized for such a procedure; designating such flow or movement. Cf. retrograde adj. 2.
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1876 G. A. Otis Med. & Surg. Hist. War of Rebellion II. ii. vii. 392 The operations comprised under this denomination [sc. internal urethrotomy] are two-fold: those of puncture or incision of urethral obstructions from before backward, or what is now known as anterograde urethrotomy, and incision of permeable callous strictures from behind forward, or retrograde urethrotomy.
1878 Med. Rec. 13 476/2 With regard to the instruments to be employed, he favored Maissonneuve's urethrotome, or any of its modifications, for the anterograde, and Civiale's..for the retrograde operations.
1908 Boston Med. & Surg. Jrnl. 3 Dec. 766/1 Of the anterograde instruments, they employed the Albarran urethrotome when the stricture was too tight to admit the Otis.
1916 Arch. Radiol. & Electrotherapy 20 263 The anterograde movement of the chyme is due to a true peristalsis.
1986 Circulation 74 105 Twenty patients..received cardioplegic solution by anterograde aortic root perfusion.
2014 P. Pittaluga et al. in J. J. Bergan & N. Bunke-Paquette Vein Bk. (ed. 2) xxv. 204/1 A reflux may be present that passes through healthy valves when a patient is in the decubitus position, because the velocity of the anterograde flow is slight.
2. Medicine. Of memory function: relating to the time after a causal event; extending forward from a given point in time; relating to present or future rather than past events. Contrasted with retrograde adj. 6.
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1892 Jrnl. Soc. Psychical Res. 5 286 Professor Janet followed with a description of a case of amnesia which differed from ordinary loss of memory in being not merely ‘retrograde’ but ‘anterograde’, i.e., the patient had not merely lost a portion of her stored recollections of the past, but also her power of acquiring new recollections.
1967 Brit. Jrnl. Psychiatry 113 120/2 Hysterical amnesia is as a rule retrograde and seldom bears on current experience (i.e. is rarely anterograde).
2005 Globe & Mail (Toronto) 11 May a20/2 Alcohol..impedes the formation of memories while you are under the influence (‘temporary anterograde amnesia’) while safeguarding memories formed just before drinking.
3. Medicine and Physiology. Of nerve conduction, synaptic transmission, or other neural processes: occurring in the normal or usual direction. Also: involved in such a process. Contrasted with retrograde adj. 4f.
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1949 W. B. Cannon & A. Rosenblueth Supersensitivity of Denervated Struct. xviii. 181 Unlike the supersensitivity caused by anterograde nerve degeneration.
1969 Jrnl. Compar. Neurol. 136 375 Experimentally-induced anterograde axonal degeneration.
1988 Nature 1 Dec. 470/1 Axonal transport..as demonstrated by robust anterograde transport of tracers.
2006 G. F. Koob & M. Le Moal Neurobiol. of Addiction vii. 320 (caption) Anandamide functions as a retrograde signaling molecule that modulates (inhibits) the release of classical anterograde transmitters by presynaptic terminals.
Derivatives
ˈanteroˌgradely adv. in the normal or usual direction; forward.
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1947 Jrnl. Nerv. & Mental Dis. 106 440 A loose network of fibers which degenerates anterogradely homolaterally and to a lesser degree also contralaterally.
1987 J. V. Priestley in A. J. Turner & H. S. Bachelard Neurochem. iii. 99 (caption) An anterogradely transported tracer injected into B would label terminals in A.
1999 R. Shiloh et al. Atlas Psychiatric Pharmacotherapy vii. 89/2 The tonus is reduced, allowing some or all of the ejaculate to pass retrogradely into the bladder instead of anterogradely into the urethra.
This entry has been updated (OED Third Edition, March 2016; most recently modified version published online December 2021).
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adj.1876