hypermutantn.adj.

Brit.

/ˌhʌɪpəˈmjuːt(ə)nt/, U.S.

/ˌhaɪpərˈmjutnt/

Origin: Formed within English, by derivation. Etymons: hyper- prefix, mutant n.

Etymology: < hyper- prefix + mutant n., after hypermutation n.

Genetics.

A. n.

1. An organism exhibiting a major phenotypic change as a result of mutation. rare. disused.

ΚΠ

1934 W. H. Manwaring in Science 25 May 468/2 ‘Convergent evolution’ is an interesting by-product of this emergence, two practically identical hyper-mutants arising from two presumably unrelated bacterial species.

2. An organism or gene sequence that undergoes or has undergone mutation at a high rate.

ΚΠ

1990 V. K. Pathak & H. M. Temin in Proc. National Acad. Sci. U.S.A. 87 6019/1 Such proviruses, which we name hypermutants, may arise through the action of an error-prone polymerase.

1994 R. Preston Hot Zone 288 It [sc. the AIDS virus] is a hypermutant, a shape shifter, spontaneously altering its character as it moves through populations and through individuals.

1996 Economist 16 Nov. 140/2 Moreover, and more worryingly, the biologists suggest that these ‘hypermutants’ may help to explain why certain pathogenic (disease-causing) bacteria are rapidly becoming resistant to antibiotics.

2000 Proc. National Acad. Sci. U.S.A. 97 14570 (caption) One sequence..is a defective G→A hypermutant.

B. adj.

That undergoes or has undergone mutation at a high rate.

ΚΠ

1990 V. K. Pathak & H. M. Temin in Proc. National Acad. Sci. U.S.A. 87 6023/1 Almost 75% of the base pair substitutions that we found were present in the hypermutant proviruses.

1996 AIDS Res. & Human Retroviruses 12 1605 The resulting sequences are like previously reported hypermutant human and simian immunodeficiency virus (HIV and SIV) genomes.

This is a new entry (OED Third Edition, December 2004; most recently modified version published online March 2022).

单词	hypermutant
释义	hypermutantn.adj. Brit. /ˌhʌɪpəˈmjuːt(ə)nt/, U.S. /ˌhaɪpərˈmjutnt/ Origin: Formed within English, by derivation. Etymons: hyper- prefix, mutant n. Etymology: < hyper- prefix + mutant n., after hypermutation n. Genetics. A. n. 1. An organism exhibiting a major phenotypic change as a result of mutation. rare. disused. ΚΠ 1934 W. H. Manwaring in Science 25 May 468/2 ‘Convergent evolution’ is an interesting by-product of this emergence, two practically identical hyper-mutants arising from two presumably unrelated bacterial species. 2. An organism or gene sequence that undergoes or has undergone mutation at a high rate. ΚΠ 1990 V. K. Pathak & H. M. Temin in Proc. National Acad. Sci. U.S.A. 87 6019/1 Such proviruses, which we name hypermutants, may arise through the action of an error-prone polymerase. 1994 R. Preston Hot Zone 288 It [sc. the AIDS virus] is a hypermutant, a shape shifter, spontaneously altering its character as it moves through populations and through individuals. 1996 Economist 16 Nov. 140/2 Moreover, and more worryingly, the biologists suggest that these ‘hypermutants’ may help to explain why certain pathogenic (disease-causing) bacteria are rapidly becoming resistant to antibiotics. 2000 Proc. National Acad. Sci. U.S.A. 97 14570 (caption) One sequence..is a defective G→A hypermutant. B. adj. That undergoes or has undergone mutation at a high rate. ΚΠ 1990 V. K. Pathak & H. M. Temin in Proc. National Acad. Sci. U.S.A. 87 6023/1 Almost 75% of the base pair substitutions that we found were present in the hypermutant proviruses. 1996 AIDS Res. & Human Retroviruses 12 1605 The resulting sequences are like previously reported hypermutant human and simian immunodeficiency virus (HIV and SIV) genomes. This is a new entry (OED Third Edition, December 2004; most recently modified version published online March 2022). < n.adj.1934
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