isoniazidn.
/ʌɪsəʊˈnʌɪəzɪd/ Pharmacology.
A white or colourless crystalline compound, C5H5N·CO·NH·NH2, which has bacteriostatic properties against mycobacteria and is used esp. in the treatment of tuberculosis.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for tuberculosis
Koch's tuberculin1890
tuberculin1891
tuberculocidin1891
tuberculocide1892
Sanocrysin1924
promizole1944
streptomycin1944
para-aminosalicylic acid1946
pyrazinamide1947
viomycin1950
Marsilid1952
thiacetazone1952
iproniazid1953
isoniazid1953
isonicotinic hydrazide1956
ethionamide1959
strep1959
rifampicin1966
rifampin1968
the world > health and disease > healing > medicines or physic > medicines for specific purpose > substances acting on bacteria > [noun] > bacteriostatic > specific
promin1937
promizole1944
thiacetazone1952
isoniazid1953
isonicotinic hydrazide1956
ethambutol1961
1953 Jrnl. Pharmacol. & Exper. Therapeutics 107 219 Isonicotinic acid hydrazide (Nydrazid), generically designated as isoniazid, has been shown to be an effective chemotherapeutic agent against experimental..and human tuberculosis.
1962 Lancet 29 Dec. 1364/2 In the second phase, since the bacilli are no longer multiplying rapidly and resistant mutants are therefore unlikely to appear, a single drug only—isoniazid—need be continued to kill off those remaining.
1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. xx. 32/2 Isoniazid (isonicotinic acid hydrazine INH) is the most powerful and effective antituberculous drug.
1973 P. Turner & A. Richens Clin. Pharmacol. xiv. 186 Isoniazid can interfere with the metabolism of pyridoxine and can cause peripheral neuritis when prolonged courses are given.
This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2018).
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n.1953