lactulosen.
/ˈlaktjʊləʊz/ Biochemistry and Pharmacology.
A synthetic disaccharide of fructose and galactose that is given as a laxative; 4-O-β- d-galactopyranosyl- d-fructose, C12H22O11.Originally called lactoketose ( Science (1929) 24 May 556/2).
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lactulose1930
1930 Montgomery & Hudson in Jrnl. Amer. Chem. Soc. 52 2101 The name lactoketose was..used for the sugar but it has been decided subsequently to name it lactulose.
1938 M. L. Wolfram in H. Gilman Org. Chem. I. xvi. 1442 The Lobry de Bruyn dilute alkali interconversion reaction was used..in obtaining the crystalline ketose of lactose (lactulose).
1983 D. J. Weatherall et al. Oxf. Textbk. Med. I. xii. 14/2 Lactulose..is useful in patients whose colons are full of hard scybala as it softens the stool partly by an osmotic effect and partly by the production of lactic acid and other organic acids.
1989 Martindale's Extra Pharmacopoeia (ed. 29) 1093 Lactulose is a synthetic disaccharide which is used in the treatment of..hepatic encephalopathy.
1991 Lancet 7 Sept. 633/1 For three weeks before admission she had been taking terodiline 25mg twice daily plus lactulose and ‘Fybogel’.
This entry has not yet been fully updated (first published 1997; most recently modified version published online March 2021).
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