| 单词 | methonium compound |
| 释义 | > as lemmasmethonium compound Any of a class of compounds consisting of a methylene chain with a trimethylammonium group, (CH3)3N+, at each end, some of which are used as ganglionic blocking agents; a salt of such a compound. Chiefly attributive, esp. in methonium compound.In the names of individual methonium compounds the number of methylene groups in the chain is indicated with a numerical prefix. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for blood-pressure disorders Neo-Synephrine1934 Priscol1938 phenylephrine1947 hexamethonium1949 Priscoline1949 methonium1950 hydralazine1952 phentolamine1953 methyldopa1954 pentolinium1954 mecamylamine1955 hydrochlorothiazide1958 pempidine1958 guanethidine1959 hydroflumethiazide1959 thiazide1959 pheniprazine1960 pargyline1961 vasodepressor1961 alpha blocker1965 clonidine1969 prazosin1970 timolol1973 1949 Jrnl. Pharmacy & Pharmacol. 1 603 An antidote exists for decamethonium iodide in hexamethonium iodide..and..this substance has been suggested for use in hypertension and vascular diseases.] 1950 Lancet 26 Aug. 353/1 (heading) ‘Medical sympathectomy’ in hypertension. A clinical study of methonium compounds. 1952 Pharmacol. Rev. 4 220 The name of ‘methonium’ compounds for the members of the polymethylene bistrimethylammonium series has been approved by the British Pharmacopoeia Commission, and it is under this name, preceded by the appropriate numerical prefix, that they are now known. 1969 Jrnl. Neurochem. 16 1173 Some members of the methonium series are..taken up by a saturable mechanism and..the uptakes can be described quantitatively by Michaelis-Menten type kinetics. 1984 Brit. Jrnl. Pharmacol. 82 623 Recovery from use-dependent block with short chain methonium compounds, up to C8, was very slow in the absence of agonist. 1990 M. Weatherall In Search of Cure (BNC) 255 Peripheral transmission at ganglia could be blocked by methonium compounds and transmission at certain nerve endings by betablockers. 1998 Proc. National Acad. Sci. U.S.A. 95 7257/1 (title) Calculated 11B–13C NMR chemical shift relationship in hypercoordinate methonium and boronium ions. < as lemmas |
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