metyraponen.

Brit.

/mᵻˈtɪrəpəʊn/,

/mᵻˈtʌɪrəpəʊn/, U.S.

/məˈtɪrəˌpoʊn/,

/məˈtaɪrəˌpoʊn/

Origin: Probably formed within English, by derivation. Etymons: methyl n., pyridyl n., English -a- , propane n., -one suffix.

Etymology: Probably < met- (in methyl n.) + -yr- (in pyridyl n.) + -a- connective (compare -i- connective) + -p- (in propane n.) + -one suffix.

Pharmacology.

A compound that inhibits the enzyme 17β-hydroxylase and prevents synthesis of glucocorticoids and mineralocorticoids by the adrenal gland, used chiefly for assessment of feedback control of the hypothalamic-pituitary axis in adrenal disease, and sometimes in the treatment of Cushing's syndrome and resistant oedema; 2-methyl-1,2-di-3-pyridyl-1-propanone, C₅H₄N·CO·C(CH₃)₂·C₅H₄N.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > [noun] > drugs used as testing agents

tuberculin1891

lepromin1929

penatin1942

sulphobromophthalein1945

toxoplasmin1948

Metopirone1960

metyrapone1962

leprolin1971

1962 Lancet 8 Dec. 1199/1 This paper reports the prevention of massive adrenal necrosis due to d.m.b.a. by the concurrent administration of metyrapone.

1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. vi. 14/2 The metyrapone test depends upon the fact that the feedback control mechanism between the adrenal cortex and the hypothalamo–pituitary axis is mediated by the circulating concentration of unbound cortisol.

1981 R. N. Hardy Endocrine Physiol. ix. 129 Drugs such as metyrapone or amphenone B block the synthesis of both glucocorticoids and mineralocorticoids by inhibiting hydroxylation.

1990 Q. Jrnl. Med. 77 1113 Failure to respond to either dexamethasone or metyrapone was found in only one of the patients with Cushing's disease.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	metyrapone
释义	metyraponen. Brit. /mᵻˈtɪrəpəʊn/, /mᵻˈtʌɪrəpəʊn/, U.S. /məˈtɪrəˌpoʊn/, /məˈtaɪrəˌpoʊn/ Origin: Probably formed within English, by derivation. Etymons: methyl n., pyridyl n., English -a- , propane n., -one suffix. Etymology: Probably < met- (in methyl n.) + -yr- (in pyridyl n.) + -a- connective (compare -i- connective) + -p- (in propane n.) + -one suffix. Pharmacology. A compound that inhibits the enzyme 17β-hydroxylase and prevents synthesis of glucocorticoids and mineralocorticoids by the adrenal gland, used chiefly for assessment of feedback control of the hypothalamic-pituitary axis in adrenal disease, and sometimes in the treatment of Cushing's syndrome and resistant oedema; 2-methyl-1,2-di-3-pyridyl-1-propanone, C₅H₄N·CO·C(CH₃)₂·C₅H₄N. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > [noun] > drugs used as testing agents tuberculin1891 lepromin1929 penatin1942 sulphobromophthalein1945 toxoplasmin1948 Metopirone1960 metyrapone1962 leprolin1971 1962 Lancet 8 Dec. 1199/1 This paper reports the prevention of massive adrenal necrosis due to d.m.b.a. by the concurrent administration of metyrapone. 1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. vi. 14/2 The metyrapone test depends upon the fact that the feedback control mechanism between the adrenal cortex and the hypothalamo–pituitary axis is mediated by the circulating concentration of unbound cortisol. 1981 R. N. Hardy Endocrine Physiol. ix. 129 Drugs such as metyrapone or amphenone B block the synthesis of both glucocorticoids and mineralocorticoids by inhibiting hydroxylation. 1990 Q. Jrnl. Med. 77 1113 Failure to respond to either dexamethasone or metyrapone was found in only one of the patients with Cushing's disease. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1962
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