mevalonicadj.

Brit.

/mɛvəˈlɒnɪk/, U.S.

/ˌmɛvəˈlɑnək/

Origin: Formed within English, by derivation. Etymons: methyl n., valeric adj., -onic suffix.

Etymology: < me- (in methyl n.) + val- (in valeric adj.) + -onic suffix.

Biochemistry.

mevalonic acid n. a carboxylic acid first identified as a growth factor for lactobacilli and later recognized to play a role in isoprenoid metabolism (see mevalonate n.); 3,5-dihydroxy-3-methylpentanoic acid, C₆H₁₂O₄.

ΘΚΠ

the world > matter > chemistry > organic chemistry > organic acids > [noun] > carboxylic acids > miscellaneous others

urobenzoic acid1836

adipic acid1838

azelaic acid1838

isethionic acid1838

rutinic acid1845

rutic acid1848

glyoxylic acid1856

malonic acid1859

piperic acid1863

butalanine1865

methacrylic acid1865

barbituric acid1866

pichuric acid1866

carboxylic acid1868

gluconic acid1871

xylic acid1872

xylidic acid1872

aconic acid1873

formobenzoic1873

nicotinic acid1873

hydracrylic acid1877

undecylenic acid1879

isonicotinic acid1883

isatoic acid1885

linolenic acid1887

hendecenoic acid1889

heptenoic acid1889

mannonic acid1890

phenolcarboxylic acid1893

naphthenic acid1894

aldonic acid1904

naphthaleneacetic acid1917

heptanoic acid1928

hexuronic acid1928

pantothenic acid1933

neuraminic acid1942

pantoic acid1945

penicillanic acid1953

mevalonic acid1957

retinoic acid1960

isobutyric acid-

1957 D. E. Wolf et al. in Jrnl. Amer. Chem. Soc. 79 1486/1 (note) The name ‘mevalonic acid’ is now being used to designate β,δ-dihydroxy-β-methylvaleric acid.

1962 H. A. Krebs in A. Pirie Lens Metabolism 351 The reaction sequence is inhibited by cholesterol itself and some of its immediate precursors by stopping an early stage, probably that giving rise to mevalonic acid.

1973 Plant Physiol. 51 110/1 Mevalonic acid-2-¹⁴C was readily incorporated into the free, esterified, and glycosidic sterol fractions of tobacco..seedlings.

1982 T. M. Devlin Textbk. Biochem. x. 508 The first compound unique to the pathway of cholesterol biosynthesis is mevalonic acid.

2000 Atherosclerosis 150 421 In the present study we evaluated the effect of atorvastatin on steady state concentrations of plasma lipids and mevalonic acid.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	mevalonic
释义	mevalonicadj. Brit. /mɛvəˈlɒnɪk/, U.S. /ˌmɛvəˈlɑnək/ Origin: Formed within English, by derivation. Etymons: methyl n., valeric adj., -onic suffix. Etymology: < me- (in methyl n.) + val- (in valeric adj.) + -onic suffix. Biochemistry. mevalonic acid n. a carboxylic acid first identified as a growth factor for lactobacilli and later recognized to play a role in isoprenoid metabolism (see mevalonate n.); 3,5-dihydroxy-3-methylpentanoic acid, C₆H₁₂O₄. ΘΚΠ the world > matter > chemistry > organic chemistry > organic acids > [noun] > carboxylic acids > miscellaneous others urobenzoic acid1836 adipic acid1838 azelaic acid1838 isethionic acid1838 rutinic acid1845 rutic acid1848 glyoxylic acid1856 malonic acid1859 piperic acid1863 butalanine1865 methacrylic acid1865 barbituric acid1866 pichuric acid1866 carboxylic acid1868 gluconic acid1871 xylic acid1872 xylidic acid1872 aconic acid1873 formobenzoic1873 nicotinic acid1873 hydracrylic acid1877 undecylenic acid1879 isonicotinic acid1883 isatoic acid1885 linolenic acid1887 hendecenoic acid1889 heptenoic acid1889 mannonic acid1890 phenolcarboxylic acid1893 naphthenic acid1894 aldonic acid1904 naphthaleneacetic acid1917 heptanoic acid1928 hexuronic acid1928 pantothenic acid1933 neuraminic acid1942 pantoic acid1945 penicillanic acid1953 mevalonic acid1957 retinoic acid1960 isobutyric acid- 1957 D. E. Wolf et al. in Jrnl. Amer. Chem. Soc. 79 1486/1 (note) The name ‘mevalonic acid’ is now being used to designate β,δ-dihydroxy-β-methylvaleric acid. 1962 H. A. Krebs in A. Pirie Lens Metabolism 351 The reaction sequence is inhibited by cholesterol itself and some of its immediate precursors by stopping an early stage, probably that giving rise to mevalonic acid. 1973 Plant Physiol. 51 110/1 Mevalonic acid-2-¹⁴C was readily incorporated into the free, esterified, and glycosidic sterol fractions of tobacco..seedlings. 1982 T. M. Devlin Textbk. Biochem. x. 508 The first compound unique to the pathway of cholesterol biosynthesis is mevalonic acid. 2000 Atherosclerosis 150 421 In the present study we evaluated the effect of atorvastatin on steady state concentrations of plasma lipids and mevalonic acid. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < adj.1957
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