mutatorn.

Brit.

/mjuːˈteɪtə/, U.S.

/ˈmjuˌteɪdər/

Origin: Partly a borrowing from Latin. Probably partly formed within English, by derivation. Etymons: Latin mūtātor ; mutate v., -or suffix.

Etymology: In quot. 1632 at sense 1 < classical Latin mūtātor a person who changes < mūtāt- , past participial stem of mūtāre to change (see mutate v.) + -or -or suffix. In later use probably independently < mutate v. + -or suffix.

1. A person who changes; something which effects a change. rare.

ΘΚΠ

the world > time > change > [noun] > one who or that which causes change

changera1398

mutator1632

innovator1638

alterator1662

turnabouta1670

alterant1750

1632 W. Lithgow Totall Disc. Trav. x. 438 Can you draw from them [sc. the French]..a greater draught, then they draw from the Italian, for first they be Imitators; next, Mutators; thirdly, Temptators; and lastly, your Plantators, in all the varieties of vanity.

1937 New Phytologist 36 49 Schulze calls his substance..a mutator and ascribes to it the role of a regulator of protein metabolism.

2. Biology. An organism, gene, etc., which is liable to mutate, or which undergoes mutation frequently (in some cases, because of the presence of a mutator gene: see sense 3).

ΚΠ

1942 Amer. Naturalist 76 202 The cultivated Rosaceae, Compositae and Citrus are notorious bud mutators, while Asparagus, Convallaria and Vinca stick to the ancestral traditions.

1963 Proc. National Acad. Sci. U.S.A. 50 1048 Abnormally high rates of spontaneous mutation have been recorded several times in certain strains of E coli and S. typhimurium. These unstable ‘mutator’ strains often generate auxotrophic mutants.

1994 R. Preston Hot Zone 288 The AIDS virus is a fast mutator; it changes constantly. It is a hypermutant.

1995 L. Garrett Coming Plague (new ed.) 664 The segment of the influenza virus responsible for its ability to infect human cells was an even more rapid mutator [than the cow virus responsible for foot-and-mouth disease].

3. Biology. In full mutator gene. A gene which increases the mutation rate of other genes.

ΘΚΠ

the world > life > biology > biological processes > genetic activity > genetic components > [noun] > gene > types of gene

sex determinant1902

sex determiner1909

inhibitor1911

multiple factor1912

modifier1915

autosomal dominant1919

autosomal recessive1919

scute1923

gene1925

suppressor1928

rate gene1932

dominigene1938

buffer1939

polygene1941

switch gene1942

mutator1943

oligogene1943

sickle cell gene1946

supergene1949

ob1950

obese1950

regulator1960

regulator gene1960

regulatory gene1960

enhancer1967

oncogene1969

virogene1969

hedgehog1980

1943 Proc. National Acad. Sci. U.S.A. 29 138 In determining the abnormal mutation rate we shall consider only those cultures which have given at least one sex-linked recessive, since this is the only indication of the presence of the ‘Mutator’ gene in the mother.

1945 Genetics 30 496 Recently, high mutation frequency in a strain of D. pseudoobscura, race B, was found to be due to a dominant mutator.

1969 Science 16 May 790/2 The presence of the Treffers mutator (mut T) gene produced a trend towards DNA of a guanine-cytosine content higher than that in the original stock.

1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) v. 233 One mutator gene encodes a defective form of the 3′-to-5′ proofreading exonuclease.

This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022).

单词	mutator
释义	mutatorn. Brit. /mjuːˈteɪtə/, U.S. /ˈmjuˌteɪdər/ Origin: Partly a borrowing from Latin. Probably partly formed within English, by derivation. Etymons: Latin mūtātor ; mutate v., -or suffix. Etymology: In quot. 1632 at sense 1 < classical Latin mūtātor a person who changes < mūtāt- , past participial stem of mūtāre to change (see mutate v.) + -or -or suffix. In later use probably independently < mutate v. + -or suffix. 1. A person who changes; something which effects a change. rare. ΘΚΠ the world > time > change > [noun] > one who or that which causes change changera1398 mutator1632 innovator1638 alterator1662 turnabouta1670 alterant1750 1632 W. Lithgow Totall Disc. Trav. x. 438 Can you draw from them [sc. the French]..a greater draught, then they draw from the Italian, for first they be Imitators; next, Mutators; thirdly, Temptators; and lastly, your Plantators, in all the varieties of vanity. 1937 New Phytologist 36 49 Schulze calls his substance..a mutator and ascribes to it the role of a regulator of protein metabolism. 2. Biology. An organism, gene, etc., which is liable to mutate, or which undergoes mutation frequently (in some cases, because of the presence of a mutator gene: see sense 3). ΚΠ 1942 Amer. Naturalist 76 202 The cultivated Rosaceae, Compositae and Citrus are notorious bud mutators, while Asparagus, Convallaria and Vinca stick to the ancestral traditions. 1963 Proc. National Acad. Sci. U.S.A. 50 1048 Abnormally high rates of spontaneous mutation have been recorded several times in certain strains of E coli and S. typhimurium. These unstable ‘mutator’ strains often generate auxotrophic mutants. 1994 R. Preston Hot Zone 288 The AIDS virus is a fast mutator; it changes constantly. It is a hypermutant. 1995 L. Garrett Coming Plague (new ed.) 664 The segment of the influenza virus responsible for its ability to infect human cells was an even more rapid mutator [than the cow virus responsible for foot-and-mouth disease]. 3. Biology. In full mutator gene. A gene which increases the mutation rate of other genes. ΘΚΠ the world > life > biology > biological processes > genetic activity > genetic components > [noun] > gene > types of gene sex determinant1902 sex determiner1909 inhibitor1911 multiple factor1912 modifier1915 autosomal dominant1919 autosomal recessive1919 scute1923 gene1925 suppressor1928 rate gene1932 dominigene1938 buffer1939 polygene1941 switch gene1942 mutator1943 oligogene1943 sickle cell gene1946 supergene1949 ob1950 obese1950 regulator1960 regulator gene1960 regulatory gene1960 enhancer1967 oncogene1969 virogene1969 hedgehog1980 1943 Proc. National Acad. Sci. U.S.A. 29 138 In determining the abnormal mutation rate we shall consider only those cultures which have given at least one sex-linked recessive, since this is the only indication of the presence of the ‘Mutator’ gene in the mother. 1945 Genetics 30 496 Recently, high mutation frequency in a strain of D. pseudoobscura, race B, was found to be due to a dominant mutator. 1969 Science 16 May 790/2 The presence of the Treffers mutator (mut T) gene produced a trend towards DNA of a guanine-cytosine content higher than that in the original stock. 1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) v. 233 One mutator gene encodes a defective form of the 3′-to-5′ proofreading exonuclease. This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022). < n.1632
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