nephrotoxicadj.
/ˌnɛfrə(ʊ)ˈtɒksɪk/, U.S. /ˌnɛfroʊˈtɑksɪk/ Medicine.
Of the nature of a nephrotoxin; having a toxic effect on the kidneys; producing kidney disease.
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nephrotoxic1902
1902 V. C. Vaughan & F. G. Novy Cellular Toxins (ed. 4) vii. 144 The blood of animals in which one ureter has remained tied for some time becomes laden with a nephrotoxic substance.
1937 Jrnl. Exper. Med. 65 564 The nephrotoxic effect induced by anti-kidney serum is dependent upon a relatively organ specific antibody, nephrotoxin.
1973 Jrnl. Pharmacol. & Exper. Therapeutics 186 593/1 Administration of the nephrotoxic agent uranyl nitrate to rats specifically stimulated organic base accumulation by renal cortical slices.
1991 Lancet 5 Jan. 25/1 Cyclosporin is nephrotoxic and can cause impaired renal function.
2000 Nephron 84 136 Those patients receiving high numbers of nephrotoxic drugs in combination with renal hypoperfusion were likely to develop acute renal failure.
This entry has been updated (OED Third Edition, September 2003; most recently modified version published online March 2022).
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adj.1902