nucleolyticadj.
/ˌnjuːklɪəˈlɪtɪk/, U.S. /ˈˌn(j)ukliəˈlɪdɪk/ 1. Biochemistry and Pathology. Causing, relating to, or designating the cleavage of nucleic acids, esp. by enzymes. Also: of or relating to the destruction of cell nuclei; karyolytic (rare).
ΚΠ
1911 P. A. Levene & F. Medigreceanu in Jrnl. Biol. Chem. 9 396 Since this reaction is brought about by an enzyme different from the other nucleolytic enzymes, it may be proper to refer to it under the name of Nucleosidase.
1953 W. H. Yudkin in G. H. Bourne & G. W. Kidder Biochem. & Physiol. Nutrition II. xvii. 270 Studies on the distribution of nucleolytic activity have shown it to be common among diverse cells.
1972 Jrnl. Pathol. 106 199 It is likely that the reticular cells and not the small macrophages take part in nucleolytic reactions.
1998 Nucleic Acids Res. 26 3762 Nucleolytic processing of chromosomal DNA is required in operations such as DNA repair, recombination and replication.
2. Surgery and Medicine. Causing or relating to the destruction of the nucleus pulposus of an intervertebral disc (cf. nucleolysis n. 3).
ΚΠ
1986 Arch. Orthopaedic & Traumatic Surg. 105 287 This method avoids..the escape of the nucleolytic agent into the spinal canal.
1987 Spine 12 556 Hyaluronidase could be of interest as a nucleolytic drug and needs further studies on optimal dosage..before injecting it into human discs.
1991 Spine 16 203 The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs.
This is a new entry (OED Third Edition, December 2003; most recently modified version published online March 2022).
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