pergoliden.
/ˈpəːɡəlʌɪd/, U.S. /ˈpərɡəˌlaɪd/ Pharmacology.
An ergot derivative which is a dopamine agonist used chiefly in the treatment of Parkinson's disease.Chemical name: 8Β-methylthiomethyl-6-propylergoline mesylate.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for Parkinsonism
amantadine1964
pergolide1979
1979 Trans. Amer. Neurol. Assoc. 104 161 Effect of pergolide mesylate, an ergoline, in animal models of Parkinson's disease: implications for therapy.
1984 Current Eye Res. 3 307 Ergot derivatives, such as bromocriptine, lergotrile and pergolide, are potent dopaminergic agonists in various biological systems.
1990 Drugs 39 491 Pergolide acts at dopamine receptors in the corpus striatum to improve locomotor activity, reducing the tremor, gait disturbances, bradykinesia or akinesia and rigidity experienced by such patients.
2000 Chicago Tribune (Nexis) 25 May c7 Pergolide is a medication that has been used successfully for short-term treatment of restless leg syndrome.
This is a new entry (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1979