penicillinasen.

Brit.

/ˌpɛnᵻˈsɪlᵻneɪz/, U.S.

/ˌpɛnəˈsɪləˌneɪz/,

/ˌpɛnəˈsɪləˌneɪs/

Origin: Formed within English, by derivation. Etymons: penicillin n., -ase suffix.

Etymology: < penicillin n. + -ase suffix. Compare French pénicillinase (1945; < English).

Biochemistry.

Any of a group of bacterial enzymes which cause the breaking of the carbon–nitrogen bond in the lactam ring of some penicillins, rendering them ineffective as antibiotics. Cf. lactamase n.

ΚΠ

1940 E. P. Abraham & E. B. Chain in Nature 28 Dec. 837/1 The activity of the enzyme, which we term penicillinase, is slight at pH5, but increases considerably towards the alkaline range of pH.

1958 Ann. Rev. Biochem. 27 176 Cephalosporin-C possesses the interesting property of being resistant to the action of some penicillinases including that produced by penicillin resistant staphylococci.

1974 M. C. Gerald Pharmacol. iv. 72 Recent research has made available new penicillins that are resistant to acid hydrolysis and penicillinase attack.

2003 Chemotherapy 49 229 FAR [= Faropenem] as well as other cephalosporins tested were highly stable to penicillinase derived from S. aureus and E. coli.

This entry has been updated (OED Third Edition, September 2005; most recently modified version published online March 2022).

单词	penicillinase
释义	penicillinasen. Brit. /ˌpɛnᵻˈsɪlᵻneɪz/, U.S. /ˌpɛnəˈsɪləˌneɪz/, /ˌpɛnəˈsɪləˌneɪs/ Origin: Formed within English, by derivation. Etymons: penicillin n., -ase suffix. Etymology: < penicillin n. + -ase suffix. Compare French pénicillinase (1945; < English). Biochemistry. Any of a group of bacterial enzymes which cause the breaking of the carbon–nitrogen bond in the lactam ring of some penicillins, rendering them ineffective as antibiotics. Cf. lactamase n. ΚΠ 1940 E. P. Abraham & E. B. Chain in Nature 28 Dec. 837/1 The activity of the enzyme, which we term penicillinase, is slight at pH5, but increases considerably towards the alkaline range of pH. 1958 Ann. Rev. Biochem. 27 176 Cephalosporin-C possesses the interesting property of being resistant to the action of some penicillinases including that produced by penicillin resistant staphylococci. 1974 M. C. Gerald Pharmacol. iv. 72 Recent research has made available new penicillins that are resistant to acid hydrolysis and penicillinase attack. 2003 Chemotherapy 49 229 FAR [= Faropenem] as well as other cephalosporins tested were highly stable to penicillinase derived from S. aureus and E. coli. This entry has been updated (OED Third Edition, September 2005; most recently modified version published online March 2022). < n.1940
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