phenothiazinen.

Brit.

/ˌfiːnəʊˈθʌɪəziːn/,

/ˌfɛnəʊˈθʌɪəziːn/, U.S.

/ˌfinoʊˈθaɪəˌzin/,

/ˌfɛnoʊˈθaɪəˌzin/

Forms: 1800s– phenthiazine, 1900s– phenothiazine.

Origin: Formed within English, by compounding. Etymons: pheno- comb. form, thiazine n. at thio- comb. form 1.

Etymology: < pheno- comb. form + thiazine n. at thio- comb. form 1. With the form phenthiazine compare phen- comb. form. Compare German Phenthiazin ( A. Bernthsen Kurzes Lehrbuch der organischen Chemie (1896) 512; the word apparently does not appear in the edition of 1891; compare quot. 1894 at sense 1).

Chemistry and Pharmacology.

1. A yellow crystalline heteroaromatic compound, C₁₂H₉NS, whose molecule consists of two benzene rings joined by a sulphur atom and a nitrogen atom, and which is used in veterinary medicine as an anthelmintic.

ΘΚΠ

the world > health and disease > healing > veterinary medicine and surgery > [noun] > medicines or applications > parasiticide

phenothiazine1894

wormer1934

thiophanate1970

albendazole1976

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > anti-psychotic tranquillizers

tranquillizer1800

thioxanthene1911

phenothiazine1940

piperoxan1950

fluphenazine1959

Melleril1959

thioridazine1959

methotrimeprazine1960

thiothixene1965

molindone1967

pimozide1968

risperidone1988

1894 G. M'Gowan tr. A. Bernthsen Text-bk. Org. Chem. (ed. 2) 539 Nile Blue springs from naphtho-phenoxazine; and the thionine dyes from phen-thiazine.

1917 Chem. Abstr. 11 Index 3903 Phenothiazine.

1940 Nature 17 Aug. 232/2 Since phenothiazine is a new and valuable vermifuge, its effect on animal tissues is of some general interest.

1974 M. C. Gerald Pharmacol. iv. 71 The phenothiazine nucleus has proved..a rather versatile progenitor of pharmacologically useful compounds.

1993 Vet. Parasitol. 46 113 Thus for Ostertagia control, anthelmintics must be divided into those that normally control all stages..and those that only control adult worms and developing larvae (levamisole, morantel, coumaphos, phenothiazine and thiabendazole).

2. A substituted derivative of this; spec. (Medicine) any of those constituting a class of antipsychotic drugs (including chlorpromazine, perphenazine, thioridazine, etc.).

ΚΠ

1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) xxxix. 586 (heading) Phenoxazines and phenthiazines.

1962 F. I. Ordway et al. Basic Astronautics xiii. 526 High-potency drugs such as the phenothiazines..could be incorporated.

1974 M. C. Gerald Pharmacol. xvi. 301 Chlorpromazine (Thorazine), the most commonly employed phenothiazine.

1984 Toxicol. Lett. 20 123 Our 10-year follow-up study shows that in North Finland the principal drug groups misused were phenthiazines and benzodiazepines.

1991 P. Grescoe Flesh Wound xi. 102 Most of the people here are unpredictable, but we control the worst actors with phenothiazines and the like.

1995 Hanover (Ont.) Post 18 July a6/2 Certain tranquilizers (eg. phenothiazine), oral hypoglycaemic agents..and sulpha medications..are all photosensitive.

This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).

单词	phenothiazine
释义	phenothiazinen. Brit. /ˌfiːnəʊˈθʌɪəziːn/, /ˌfɛnəʊˈθʌɪəziːn/, U.S. /ˌfinoʊˈθaɪəˌzin/, /ˌfɛnoʊˈθaɪəˌzin/ Forms: 1800s– phenthiazine, 1900s– phenothiazine. Origin: Formed within English, by compounding. Etymons: pheno- comb. form, thiazine n. at thio- comb. form 1. Etymology: < pheno- comb. form + thiazine n. at thio- comb. form 1. With the form phenthiazine compare phen- comb. form. Compare German Phenthiazin ( A. Bernthsen Kurzes Lehrbuch der organischen Chemie (1896) 512; the word apparently does not appear in the edition of 1891; compare quot. 1894 at sense 1). Chemistry and Pharmacology. 1. A yellow crystalline heteroaromatic compound, C₁₂H₉NS, whose molecule consists of two benzene rings joined by a sulphur atom and a nitrogen atom, and which is used in veterinary medicine as an anthelmintic. ΘΚΠ the world > health and disease > healing > veterinary medicine and surgery > [noun] > medicines or applications > parasiticide phenothiazine1894 wormer1934 thiophanate1970 albendazole1976 the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > anti-psychotic tranquillizers tranquillizer1800 thioxanthene1911 phenothiazine1940 piperoxan1950 fluphenazine1959 Melleril1959 thioridazine1959 methotrimeprazine1960 thiothixene1965 molindone1967 pimozide1968 risperidone1988 1894 G. M'Gowan tr. A. Bernthsen Text-bk. Org. Chem. (ed. 2) 539 Nile Blue springs from naphtho-phenoxazine; and the thionine dyes from phen-thiazine. 1917 Chem. Abstr. 11 Index 3903 Phenothiazine. 1940 Nature 17 Aug. 232/2 Since phenothiazine is a new and valuable vermifuge, its effect on animal tissues is of some general interest. 1974 M. C. Gerald Pharmacol. iv. 71 The phenothiazine nucleus has proved..a rather versatile progenitor of pharmacologically useful compounds. 1993 Vet. Parasitol. 46 113 Thus for Ostertagia control, anthelmintics must be divided into those that normally control all stages..and those that only control adult worms and developing larvae (levamisole, morantel, coumaphos, phenothiazine and thiabendazole). 2. A substituted derivative of this; spec. (Medicine) any of those constituting a class of antipsychotic drugs (including chlorpromazine, perphenazine, thioridazine, etc.). ΚΠ 1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) xxxix. 586 (heading) Phenoxazines and phenthiazines. 1962 F. I. Ordway et al. Basic Astronautics xiii. 526 High-potency drugs such as the phenothiazines..could be incorporated. 1974 M. C. Gerald Pharmacol. xvi. 301 Chlorpromazine (Thorazine), the most commonly employed phenothiazine. 1984 Toxicol. Lett. 20 123 Our 10-year follow-up study shows that in North Finland the principal drug groups misused were phenthiazines and benzodiazepines. 1991 P. Grescoe Flesh Wound xi. 102 Most of the people here are unpredictable, but we control the worst actors with phenothiazines and the like. 1995 Hanover (Ont.) Post 18 July a6/2 Certain tranquilizers (eg. phenothiazine), oral hypoglycaemic agents..and sulpha medications..are all photosensitive. This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022). < n.1894
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