phentolaminen.
/fɛnˈtɒləmiːn/, U.S. /fɛnˈtɑləˌmin/ Pharmacology.
An alpha blocker used as a vasodilator, esp. in the management of hypertensive crises caused by phaeochromocytoma.Chemical name: 2-[N-(m-hydroxyphenyl)-p-toluidinomethyl]imidazoline, C17H19N3O.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for blood-pressure disorders
Neo-Synephrine1934
Priscol1938
phenylephrine1947
hexamethonium1949
Priscoline1949
methonium1950
hydralazine1952
phentolamine1953
methyldopa1954
pentolinium1954
mecamylamine1955
hydrochlorothiazide1958
pempidine1958
guanethidine1959
hydroflumethiazide1959
thiazide1959
pheniprazine1960
pargyline1961
vasodepressor1961
alpha blocker1965
clonidine1969
prazosin1970
timolol1973
1953 Jrnl. Amer. Med. Assoc. 15 Aug. 1533/2 Phentolamine hydrochloride, a salt of phentolamine base, is suitable for oral administration and acts as a potent adrenergic blocking agent, producing adrenolytic and sympatholytic effects.
1961 L. C. Martin Clin. Endocrinol. (ed. 3) vi. 182 Phentolamine is the most reliable of the adrenolytic substances both for diagnosis of phæochromocytoma and for use during its removal.
1972 Materials & Technol. V. xxi. 810 Alpha receptor blockers such as tolazoline may be used in the treatment of peripheral blood vessel spasm, while phentolamine is used to treat hypertensive (high blood pressure) crises.
1998 New Scientist 19 Dec. 24/3 Phentolamine..has been shown to help up to forty per cent of men with mild to moderate impotence, with nasal congestion as the main side effect.
This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1953