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单词 phosphoenolpyruvate carboxykinase
释义

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phosphoenolpyruvate carboxykinase
carboxykinase n.
Brit. /kɑːˌbɒksɪˈkʌɪneɪz/
,
U.S. /kɑrˌbɑksiˈkaɪˌneɪz/
,
/kɑrˌbɑksiˈkaɪˌneɪs/
a kinase that removes a carboxyl group; spec. (in full phosphoenolpyruvate carboxykinase) an enzyme that brings about the formation of phosphoenolpyruvate by the decarboxylation and phosphorylation of oxaloacetate, as one of the steps in gluconeogenesis in animals and in carbon fixation in plants.
ΚΠ
1959 Biochimica et Biophysica Acta 35 541 Fixation by the PEP carboxylase (PEP + Mg) and PEP carboxykinase (PEP + ADP + Mn) enzyme systems slowly decreased.
1961 Proc. National Acad. Sci. U.S.A. 47 1112 The enzyme catalyzing this reaction, phospho-enol-pyruvate carboxykinase, has only a very low activity in rat heart.
1986 Proc. Royal Soc. B. 228 487 In algae from M. verrucosa the activities of the carboxykinases were higher in cells grown at lower than at higher irradiances.
2003 W. E. Winter in M. Silink et al. Type 2 Diabetes in Childhood & Adolescence xi. 216 There are several genes or loci where a positive association has been described with susceptibility to type 2 diabetes... These genes/loci include..phosphoenolpyruvate carboxykinase, PPARG and prohormone convertase 2.
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