podophyllotoxinn.

Brit.

/ˌpɒdə(ʊ)ˌfɪlə(ʊ)ˈtɒksɪn/, U.S.

/ˈˌpɑdoʊˌfɪləˈtɑks(ə)n/

Origin: A borrowing from German. Etymon: German Podophyllotoxin.

Etymology: < German Podophyllotoxin (V. Podwissotzki 1881, in Pharm. Zeitschr. für Russland 20 142) < podophyll- (in Podophyllin podophyllin n.) + -o- -o- connective + Toxin toxin n. Compare earlier podophyllin n.

Pharmacology.

A glucoside, C₂₂H₂₂O₈, derived from podophyllin, which is used for its antimitotic properties in preparations for the treatment of genital warts, and in the manufacture of some antineoplastic drugs.

ΚΠ

1888 V. Podwissotzki in Pharm. Jrnl. & Trans. 12 217/1 The author gives up the name podophyllin, hitherto applied to the crude precipitated resin, and calls his pure product..‘podophyllotoxin’.

1900 W. A. N. Dorland Amer. Illustr. Med. Dict. 518/1 The rhizome and roots of P. peltatum..contain a resin, podophyllin, and a constituent, podophyllotoxin..used in chronic constipation, torpor of the liver etc.

1947 Science 25 Apr. 433 The rhizomes of the plant yield from 3 to 10 percent of resin consisting of podophyllotoxin..and small amounts of resin glycosides..etc.

1976 Biochemistry 15 5435 The action of podophyllotoxin on nucleoside transport appears unrelated to its effect on microtubule assembly.

2000 J. Mann Murder, Magic, & Med. (rev. ed.) iv. 234 Many plant-derived anti-cancer agents act via this mechanism, and, of these, colchicine, podophyllotoxin, and the vinca alkaloids have the closest associations with folk medicine.

This is a new entry (OED Third Edition, September 2006; most recently modified version published online March 2022).

单词	podophyllotoxin
释义	podophyllotoxinn. Brit. /ˌpɒdə(ʊ)ˌfɪlə(ʊ)ˈtɒksɪn/, U.S. /ˈˌpɑdoʊˌfɪləˈtɑks(ə)n/ Origin: A borrowing from German. Etymon: German Podophyllotoxin. Etymology: < German Podophyllotoxin (V. Podwissotzki 1881, in Pharm. Zeitschr. für Russland 20 142) < podophyll- (in Podophyllin podophyllin n.) + -o- -o- connective + Toxin toxin n. Compare earlier podophyllin n. Pharmacology. A glucoside, C₂₂H₂₂O₈, derived from podophyllin, which is used for its antimitotic properties in preparations for the treatment of genital warts, and in the manufacture of some antineoplastic drugs. ΚΠ 1888 V. Podwissotzki in Pharm. Jrnl. & Trans. 12 217/1 The author gives up the name podophyllin, hitherto applied to the crude precipitated resin, and calls his pure product..‘podophyllotoxin’. 1900 W. A. N. Dorland Amer. Illustr. Med. Dict. 518/1 The rhizome and roots of P. peltatum..contain a resin, podophyllin, and a constituent, podophyllotoxin..used in chronic constipation, torpor of the liver etc. 1947 Science 25 Apr. 433 The rhizomes of the plant yield from 3 to 10 percent of resin consisting of podophyllotoxin..and small amounts of resin glycosides..etc. 1976 Biochemistry 15 5435 The action of podophyllotoxin on nucleoside transport appears unrelated to its effect on microtubule assembly. 2000 J. Mann Murder, Magic, & Med. (rev. ed.) iv. 234 Many plant-derived anti-cancer agents act via this mechanism, and, of these, colchicine, podophyllotoxin, and the vinca alkaloids have the closest associations with folk medicine. This is a new entry (OED Third Edition, September 2006; most recently modified version published online March 2022). < n.1888
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