Pribnow boxn.

Brit.

/ˈprɪbnəʊ ˌbɒks/, U.S.

/ˈprɪbnoʊ ˌbɑks/

Origin: From a proper name, combined with an English element. Etymons: proper name Pribnow , box n.²

Etymology: < the name of David Pribnow (born 1948), U.S. geneticist, who described the sequence ( Proc. National Acad. Sci. U.S.A. 72 (1975) 784) + box n.²

Molecular Biology.

A short conserved sequence of DNA nucleotides that occurs in the promoter region of the genes of prokaryotes, and is the part of the gene that interacts directly with RNA polymerase.

ΚΠ

1976 W. Gilbert in R. Losick & M. Chamberlin RNA Polymerase 195 Pribnow..observed that there is a region of approximate homology in all of the sequences... This produces a better fit within the ‘Pribnow box’.

1988 L. Stryer Biochem. (ed. 3) v. 98 In bacteria, two sequences on the 5′ (upstream) side of the first nucleotide to be transcribed are important... One of them, called the Pribnow box, has the consensus sequence TATAAT.

1995 Proc. National Acad. Sci. U.S.A. 92 3619/2 An atypical feature of this promoter is that transcription initiates 22 bp downstream from the Pribnow box.

This is a new entry (OED Third Edition, March 2007; most recently modified version published online March 2022).

单词	pribnow box
释义	Pribnow boxn. Brit. /ˈprɪbnəʊ ˌbɒks/, U.S. /ˈprɪbnoʊ ˌbɑks/ Origin: From a proper name, combined with an English element. Etymons: proper name Pribnow , box n.² Etymology: < the name of David Pribnow (born 1948), U.S. geneticist, who described the sequence ( Proc. National Acad. Sci. U.S.A. 72 (1975) 784) + box n.² Molecular Biology. A short conserved sequence of DNA nucleotides that occurs in the promoter region of the genes of prokaryotes, and is the part of the gene that interacts directly with RNA polymerase. ΚΠ 1976 W. Gilbert in R. Losick & M. Chamberlin RNA Polymerase 195 Pribnow..observed that there is a region of approximate homology in all of the sequences... This produces a better fit within the ‘Pribnow box’. 1988 L. Stryer Biochem. (ed. 3) v. 98 In bacteria, two sequences on the 5′ (upstream) side of the first nucleotide to be transcribed are important... One of them, called the Pribnow box, has the consensus sequence TATAAT. 1995 Proc. National Acad. Sci. U.S.A. 92 3619/2 An atypical feature of this promoter is that transcription initiates 22 bp downstream from the Pribnow box. This is a new entry (OED Third Edition, March 2007; most recently modified version published online March 2022). < n.1976
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