Prontosiln.

1935 Lancet 28 Sept. 752/1 The chemotherapy of protozoal and bacterial disease (with special reference to..Prontosil, a new azo dyestuff in streptococcal infections).

1942 Endeavour July 122/2 The origin of these and other developments of bacterial chemotherapy was the synthesis by Mietzsch and Klaren of the drug known as prontosil.

1972 ‘J. Herriot’ It shouldn't happen to Vet (1973) xxi. 143 Just a suggestion, James..I honestly think that the situation calls for a little Prontosil.

1992 Independent 19 May 13/3 Bovet's first major discovery was that the dye Prontosil was an active agent in curing bacterial infections in man.

1937 Lancet 27 Feb. 510/1 From the 12th to the 29th the patient also received one tablet of Prontosil Album by mouth every six hours.

1953 R. W. Fairbrother Text-bk. Bacteriol. (ed. 7) vii. 69 This gave rise to a chaotic state, in which similar derivatives were sold under different names; for example, prontosil album, streptocide, proseptine, colsulanyde, sulphoamide P, to name only a few, all have sulphanilamide as the active principle.

1993 J. E. Lesch in S. H. Mauskopf Chem. Sci. in Mod. World ii. 201 Sulfanilamide (I. G. Farben trade name: Prontosil album or Prontalbin).

1938 Brit. Med. Jrnl. 8 Jan. 104/2 I have obtained successful results in the treatment of erysipelas and acute dermatitis by using as a local application prontosil red, 7½ grains being dissolved in 1 oz. of distilled water.

2002 R. Porter Blood & Guts v. 103 Searching, like Ehrlich, for chemical remedies, Domagk found that Prontosil red, a brilliant red dye, cured mice injected with a lethal dose of streptococci.

1938 Lancet 10 Sept. 647/1 The new rule..will apply not only to sulphanilamide but to related substances including products sold under the following names:..Prontosil rubrum.., Prontosil Soluble, [etc.].

1987 Brit. Med. Jrnl. 22 Aug. 489/1 Prontosil rubrum, patented in 1932, was used extensively on the continent from 1935 onwards.

1936 Lancet 11 July 107/2 There seems to be some risk of toxic reactions associated with the administration of Prontosil (soluble) intravenously.]

1936 Lancet 5 Dec. 1323/2 When prontosil soluble was substituted for the sulphonamide, there was no bactericidal effect.

1971 Biogr. Mem. Fellows Royal Soc. 17 118 Sulphaniliamide has a direct inhibitory effect on streptococci in blood, a property not possessed by prontosil or prontosil soluble.