progesteronen.
/prəˈdʒɛstərəʊn/, U.S. /proʊˈdʒɛstəˌroʊn/ Physiology and Medicine.
A steroid hormone produced by the corpus luteum and the placenta (or made synthetically) which is responsible for the secretory changes in the uterine lining in preparation for implantation of a fertilized ovum and is also necessary for the maintenance of pregnancy. Progesterone is used pharmacologically in the treatment of menstrual disorders and repeated miscarriage, and in contraceptives. Chemical name: 4-pregnene-3,20-dione; C21H30O2.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun]
epinephrine1899
pituitrin1909
oxytocin1927
Pitocin1929
Pitressin1929
progestin1930
progesterone1935
methyltestosterone1936
pregnenolone1936
hexœstrol1939
stilboestrol1939
hydroxyprogesterone1941
progestogen1941
Premarin1942
hydroxycorticosterone1943
gestagen1948
hydrocortisone1951
cortisol1953
fluorohydrocortisone1954
isophane1954
prednisolone1955
prednisone1955
norethisterone1956
norethynodrel1957
dexamethasone1958
fludrocortisone1958
norethindrone1960
antidiuretic hormone1961
medroxyprogesterone1962
Pergonal1963
mesterolone1965
norgestrel1966
quinestrol1966
pancuronium1967
pentagastrin1967
levonorgestrel1977
1935 W. M. Allen et al. in Nature 24 Aug. 303/2 Heretofore, two different names have been used in the literature for this hormone (progestin, luteosterone). For the sake of international uniformity, we agree to use..the name progesterone for the pure hormone.
1949 L. F. Fieser & M. Fieser Nat. Products related to Phenanthrene (ed. 3) iv. 300 There are two types of female sex hormones, exemplified by the estrogens: estradiol, estrone, and estriol; and by progesterone, the sole natural progestational hormone or gestogen.
1957 Times 2 Dec. p. vi/2 When P.M.S. is used in conjunction with a steroid hormone progesterone it will bring maiden sheep into season to produce an extra crop of lambs in their second summer (six months earlier than normal).
1974 Daily Colonist (Victoria, Brit. Columbia) 25 Aug. 26/2 By 1954, Chang and Pincus had found two progesterone hormones that worked. The birth-control pill was born.
1985 Brit. Med. Jrnl. 1 June 1620/1 Our findings confirm descriptive reports of beneficial effects of progesterone on the symptoms of premenstrual tension.
2002 Vogue Oct. 270/1 The discovery that it also caused cancer of the uterus was only a temporary setback; Wyeth Pharmaceuticals..quickly came out with Prempro, a combination of Premarin and synthetic progesterone.
Derivatives
proˈgesterone-like adj. resembling (that of) progesterone.
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1937 Proc. Royal Soc. 1936–7 B. 121 579 Androstenedione..is more similar to progesterone than is testosterone, but it has less progesterone-like activity.
1992 Science 26 June 1754/3 Concerns over the safety of..another progesterone-like contraceptive.
proˌgesterone-ˈonly adj. designating methods of contraception that use progesterone or a progestogen without oestrogen; cf. progestogen-only adj. at progestogen n. Derivatives.
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1969 Jrnl. Amer. Med. Assoc. 207 1273 Alterations of blood coagulate factors were noted to occur in pill users, but women consuming progesterone-only pills did not show these changes.
2005 Contraception 72 26/1 For progesterone-only methods, a high proportion of users will be affected by irregular menstruation.
This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).
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n.1935