> as lemmas

1939 C. H. Kellaway & E. R. Trethewie in Austral. Jrnl. Exper. Biol. 17 227 The perfusate was also tested for the presence of the substance described by Feldberg and Kellaway (1938) which, after a latent interval, causes contraction of the gut followed by slow relaxation and by characteristic after-changes in the excitability of the muscle. This substance we have called S.R.S. (slow reacting substance).

1955 W. E. Brocklehurst in Jrnl. Physiol. 128 1 ⁋ The occurrence of a slow-reacting substance together with histamine, in the perfusate coming from the isolated lung of a guinea-pig during anaphylactic shock, has been reported previously... The substance has been provisionally named ‘SRS-A’ (slow-reacting substance in anaphylaxis) to differentiate it from the considerable number of ill-defined gut-contracting substances to which the term ‘SRS’ has been applied.

1958 Pharmacol. Rev. 10 422 When egg yolk is incubated with cobra venom a slow reacting substance (SRS-C) is formed.

1964 W. G. Smith Allergy & Tissue Metabolism i. 14 Evidence for the existence of chemical mediators of anaphylaxis other than histamine has existed since 1940. Recent work on one of these, the slow reacting substance of anaphylaxis (SRS-A), led to the discovery that the hypersensitive state exerts a profound influence on tissue metabolism.

1979 Nature 6 Sept. 14/2 SRS has now been identified as a novel cysteinyl derivative of arachidonic acid.