单词 | substitution mutation |
释义 | > as lemmassubstitution mutation 10. Genetics. The replacement of one nucleotide or amino acid for another in a DNA or protein molecule; an instance of this. Frequently attributive, esp. in substitution mutation. Cf. point mutation n. at point n.1 Compounds 2. ΚΠ 1957 V. M. Ingram in Nature 17 Aug. 328/1 A substitution in the nucleic acids leads to a substitution in the poly-peptide. 1980 Proc. National Acad. Sci. U.S.A. 77 6491/1 Viruses with substitution mutations in one of the T antigen binding sites were shown to have reduced rates of DNA synthesis at low temperatures. 1990 Science 31 Aug. 1025/1 This single amino acid substitution changes the hydropathy profile of the flanking peptide segment. 2004 J. Adds et al. Genetics, Evol. & Biodiversity (rev. ed.) vi. 93 Sickle-cell anaemia arises because of a substitution mutation in a single codon, which specifies valine instead of glutamic acid. < as lemmas |
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